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Psychotherapy plus anti-depressant for panic disorder with or without agoraphobia: systematic review. British Journal of Psychiatry 2006; Volume 188; pages 305-312.

Furukawa, T. A., Watanabe, N., and Churchill, R.

Psychotherapy, medication, or both can be used to treat agoraphobia. The advantage of using both has been a topic of debate. This recent meta-analysis (combining the results of 21 randomized and controlled studies) suggests that:

1) The combination of psychotherapy and use of anti-depressants is more effective than using just one of these treatments as long as treatment continues.

2) After treatment stops, the combination of both psychotherapy and anti-depressants is more effective than the use of anti-depressants alone at follow-up, however, not more effective than psychotherapy alone.

In other words, if you are undergoing psychotherapy for agoraphobia, taking an anti-depressant will increase your likelihood of recovery and symptom relief.

But....once your treatment is over, only the psychotherapy has lasting effects. The quality of psychotherapy is what will help you stay well. Anti-depressants only help your recovery while you are taking them and do not have any lasting effects after you finish taking them.

The moral of the story is, make psychotherapy your primary treatment for agoraphobia and add an anti-depressant if you think it might help you during recovery. Also, remember that anti-depressants are prescribed to people with agoraphobia because they help prevent panic attacks. They are not as likely to be effective in treating general or free-floating anxiety as benzodiazepines.

Never rely entirely on an anti-depressant, or any other medication for recovery from agoraphobia.

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