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Classic conditioning and dysfunctional cognitions in patients with panic disorder and agoraphobia treated with an implantable cardioverter/defibrilator. Psychosomatic Medicine, Volume 63, 2001, Pages 231-238.

F. Godemann, MD; B. Ahrens, MD; S. Behrens, MD; R. Berthold, MD; C. Gandor, MD; F. Lampe, MD; and M. Linden, MD. Free University of  Berlin; Berlin, Germany.

Summary:

This study offers evidence for the role of classical conditioning in the development of panic disorder and agoraphobia.

By the theory of classical conditioning, people develop panic disorder and agoraphobia when they misinterpret the symptoms of an initial panic attack (rapid heartbeat, shallow breathing, dizziness, etc.) and conclude that  their body has experienced a physical catastrophe.They associate the physical symptoms with the place or situation they were in at the time of the panic attack. Since they don't understand what happened to them and think that the panic attack meant physical danger, they avoid the place or situation they associate with the panic symptoms.

Fear of having another panic episode, paradoxically, leads to more panic attacks in other places and situations until the fear generalizes. As the fear generalizes, people who develop agoraphobia start avoiding so many places or situations that eventually, they only feel safe at home.

This study found that of 72 patients with implantable cardioverter defibrillators (pacemakers),  14 patients (or 19.4%) met the criteria for panic disorder and/or agoraphobia (far above the lifetime prevalence for panic disorder and/or agoraphobia of 2.5% to 3%).

When interviewed, patients that developed panic disorder and/or agoraphobia reported more fear of shocks from their pacemakers, experienced more anxiety related to the shocks, and observed their own bodies more intensively to check for irregular heartbeats that might lead to shock. In other words, they were living in a state of shock expectancy unlike the patients who did not develop panic disorders.

The patients who developed agoraphobia started avoiding any place or situation they associated with irregular heartbeats which led to a shocks from their pacemaker.

These patients had learned to associate feelings of panic and anxiety with shocks from their pacemakers, and then learned to associate the panic and anxiety with places or situations in which it occurred - which is classical conditioning at its core.

Of course, the dysfunctional thinking also contributed to the onset of panic disorder and agoraphobia. The panic disorder and agoraphobia patients perceived the pacemaker shocks as a physical threat.

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